Practical Fragments has several entries on pan-assay
interference compounds, or PAINS: see here for an introduction, here for their
(mis)incorporation into a fragment library, here for the sad results of such
misincorporations, here for a much longer review, and here for something that
will hopefully bring a smile to your face after reading the previous tales of
woe.
But artifacts are not only (or even primarily!) restricted
to fragments, so Michael Walters at The University of Minnesota has established
a blog devoted to PAINS (www.htspains.com).
As with any blog, success depends to a large degree on
engagement with the broader community, so please check it out – and leave
comments!
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