It is said that if you see inside a hotdog factory you'd never eat a hotdog again. So, how did this hotdog get made? Flash back 3 years, and Don Huddler (at that time at GSK) reaches out to me and says, "Hey do you have a contact at Wiley. I have a great idea for a book." "Sure Don, here you go."
A week or so later, Don invites me to lunch so we go to greatest restaurant ever!!! Over lunch , and maybe my second beer, Don says, lets write this together. After almost choking on my Cajun Meatloaf GC, I said NO WAY!!! There may have been at least one more beer involved but I agreed after Don said he would do all the heavy lifting.
Flash forward a few weeks, and Wiley accepted our book proposal, with 30 listed chapters, with 5 sections. Part of the fun part is that they send your proposal out for review, so just like a paper, you get reviewer comments. You then sign a contract with the Publisher that says you will deliver so many pages: 556 in our case by 31Jan2016 (14 months after the contract was signed). Don had already defined many of the authors who he had thought would be appropriate. So, at this point, you send out letters to authors and ask them to contribute. So, "You would be perfect to write a chapter for our upcoming book on
So, what did I learn co-editing this book? No matter how many beers I get fed, I will never EVER edit a book again. There is actually a word ambit. I have a reputation for being "provocative" (from a reviewer); this probably didn't help. The quality of the contact at the publisher makes a huge difference. I hope our contact at Wiley was new and inexperienced because this experience was far worse than the first time I did the book.
So, what is inside the book? 291 pages (out of a promised 556). There are 14 chapters of awesomeness, featuring people featured on this site previously. This book is focused on biophysical methods and how they are used to triage and advance leads. Many of these topics have been covered in depth on this site: thermodynamics, protein-protein interactions, HDX, MST, SPR, WAC, 1D NMR, Protein NMR, and how to use them in terms of residence time. There are two case studies, one from Pfizer and one from FOB (Friend of the Blog) Michelle Arkin. Lastly, and you can figure this out, there is a chapter from Martin Scanlon on fragment libraries. I won't go into actually reviewing the book; that would be a major conflict of interest (I do have a financial interest in it and Don and I need to pay for that indexing!).
I would appreciate comments on it here, and of course any other questions I would be happy to answer.