I am not sure how many of you follow the discussion in the LinkedIn FBDD group (Dan and I try to cross post as much as possible), but Ben Davis started a discussion based on a status update I had (how meta and 21st century of us). How many commercially available fragment libraries come with the associated 1H spectrum (for NMR screening). I only know of Maybridge's collection having 1H spectra. However, I would think most companies would have the spectrum as part of their QC (or I hope they would).
That leads into the second point of discussion: how do you QC your collection? I would think LC-MS and NMR are a minimum. But, what do people do for solubility? The old stick-it-in-solution-and-see-if-it-craps-out or something more "science-y"?
Lastly, I just received word this morning in my Inbox that Infarmatik has closed up shop. I had heard it as a rumor, but now its real.
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