The fragment-screening methods poll is now closed, and the results are pretty interesting:
No technique is dominant, though SPR and ligand-detected NMR are each used by more than 40% of respondents. Thermal shift assays are also popular, with about one-third of people using them.
X-ray crystallography was used by just under a quarter of respondents, less than computational screening and not much more than reported using protein-detected NMR, which is surprising given the challenges of advancing fragments in the absence of structures.
Some of the other techniques such as ITC are still pretty niche at less than 10%, though it will be interesting to revisit this survey in a couple years and see how things change.