The fragment-based community is very diverse, with practitioners coming from biochemistry, biophysics, chemistry, computational chemistry, and many other disciplines. Communicating job openings to such a fragmented community can be difficult, but we think Practical Fragments can provide a common place for employers who want to build up fragment expertise of any flavor. If you have an opening you are trying to fill, please add it as a comment to this post. These comments will then be listed in the “Job Openings” link under the “Links of Utility” heading on the right side of the page, so they will always be easy to find.
(Note: this is for positions in fragment-based drug discovery only. There is also a LinkedIn group that lists jobs with a broader but overlapping focus.)
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We currently have a number of postdoctoral positions on FBDD projects. Details of the positions can be obtained from the following website
http://www.monash.edu.au/jobs/
under the "Academic" listing.
Position: Biology Scientist
Carmot Therapeutics, Inc. is a biotech start-up located in San Francisco, focused on the discovery of small molecule drugs for unmet medical needs. Carmot is applying an innovative and transformative technology, Chemotype Evolution, to identify superior drug candidates for challenging therapeutic targets. We have just created a new position for an ambitious scientist to join our biology discovery team.
In this research position you will participate in the discovery and advancement of compounds for the treatment of major human diseases. You will play a leading role in applying Carmot’s transformative discovery technology, Chemotype Evolution, to identify novel small molecule drug candidates. In this position, you will be working closely with other scientists in a multidisciplinary team and will have to successfully interpret and integrate diverse information to identify the best path forward. You will be working in a fast-paced environment and must be motivated by novel challenges and inspired by the deployment of innovative and creative solutions.
Your primary responsibilities will include:
Research planning and experimental design.
Performing experiments in the areas of protein engineering, biochemistry, assay development, enzymology, and compound screening.
Performing mechanistic and biophysical studies of small molecule compounds that modulate enzyme activity or protein-protein interactions.
Working with robotics equipment for assay automation.
Presentation of research progress at team meetings and company meetings and communication with external collaborators
Required experience and skills:
A PhD in biochemistry or related field, with a minimum of 3 years of post-doctoral or industry experience in drug discovery and characterization of compound-protein interactions. The ideal candidate will have a depth of experience with assay development, enzymology and/or biophysical techniques.
Experience with robotics and assay automation is desirable.
Strong scientific leadership skills and the ability and expertise to work within a multi-disciplinary team of peers and outside experts. Candidates must be able to work independently and have shown sustained research productivity demonstrated by a track record of publications and/or success in industry.
Candidates must possess excellent data analysis skills and strong verbal and written communication skills.
To apply, please forward your resume and contact information to careers@carmot.us and put “Bio 111” in subject line.
Astex Pharmaceuticals (UK) is starting a programme of 3-year Postdoctoral Fellowships under the banner of 'Sustaining Innovation'. Up to five positions will be available in 2014. These posts are based in Cambridge, UK, and adverts have recently been posted in Nature and New Scientist.
The Sustaining Innovation Fellowships are an opportunity to work with Astex scientists and benefit from our drug discovery experience, in order to develop and test new methods, tools and technologies in FBDD and cancer biology.
The posts will suit excellent, independent and self-motivated researchers who will take advantage of Astex's external network of scientific collaborations as well as its internal FBDD expertise.
Further details on the programme can be found on the Astex careers pages: http://astx.com/about/careers/. Applicants may also propose their own projects if relevant.
To apply, send a CV and covering letter to HR.UK@astx.com indicating your area of expertise or interest in the subject line.
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