Natural products have led to many approved drugs, and there is an increasing appreciation that Nature often knows best. Indeed, several published fragment libraries incorporate natural products or natural product-like molecules (see for example here, here, and here). With all this attention, it was inevitable that commercial fragment suppliers would spot this market need.
SerpentesOleum, Inc. has just launched a library they call FUNK: Fragments Uncovered in Natural Kompounds. This set consists of several hundred natural products and derived fragments carefully selected to maximize hit rates. For example:
The company has screened their library against targets such as PTP1B and falcipain-1 and obtained remarkably high hit rates in functional assays. In fact, SerpentesOleum is so confident that they’re offering a money-back guarantee if you don’t obtain at least one active against your target, no matter what it is. Looking at the structures of their compounds, I have no reason to doubt their claim.