It’s been almost two years since our last attempt at cataloging companies doing fragment-based lead discovery. That list contained 19 entries, and 5 others were mentioned in the comments section. A paper just published online by Phil Hajduk and colleagues at Abbott in J. Comput. Aided Mol. Des. provides another list of 19 companies, which has inspired Practical Fragments to combine the two to provide what we hope is the most comprehensive list of companies working in FBLD. (The paper itself is worth reading too for insights into how fragment screening has evolved. For example, Abbott pioneered the use of NMR for finding and characterizing fragments, but now functional screening, modeling, and X-ray crystallography are dominant.)
Companies doing FBLD:
Ansaris (previously Locus)
Crystax Pharmaceuticals (web site seems down - are they still around?)
Emerald BioStructures (from deCODE)
Graffinity Pharmaceuticals (NovAliX)
Johnson & Johnson
Nerviano Medical Sciences
Structure Based Design
Unlike the previous list, this one also includes large pharmaceutical companies known to be active in FBLD. Companies that have been acquired or merged are listed separately if they maintain separate web sites. The list excludes companies solely focused on selling fragment libraries, as these are covered separately.
The current list includes some 44 companies, which illustrates how widespread FBLD has become. The continuity is also encouraging: despite the challenging economic environment of the last few years, aside from a few acquisitions, a name change, and a spin-off, all the companies from the 2009 list are still around (with the possible exception of Crystax).
I’m sure the list is still incomplete, so if you know of someone else please add them to the comment section.