The number of ways to find fragments just keeps growing. A few weeks ago we discussed WAC, which takes its place alongside ITC, SPR, MS, TINS, and more traditional methods such as NMR, X-ray and biochemical screening. However, all of these approaches are somewhat reductionist, relying on isolated target proteins. In an effort to bring the whole organism into the picture, our friends at the University of Shutka, Russia, have come up with an approach they call “Fragments in Bodies,” or FIB.
The researchers have assembled a collection of very small fragments, purchased for the most part from Lilliput Pharmaceuticals. These are then screened in mouse models to look for positive phenotypic effects.
The researchers face some unique challenges. For example, it is difficult to measure changes in body mass as the animals need to consume such large amounts of fragments that they can become somewhat bloated. Still, if the animals can be safely dosed with massive amounts of micro-molecules, "FIB"ing could provide very good starting points for further work!