What is the current status of FBDD based drugs in the clinic.
Justin Bower from AZ posted:
ABT 263 (Phase II Bcl-2/Bcl-xl inhibitor) Abbott
ABT 869 (VEGF & PDGFR Phase I) Abbott
SGX-523 (Met Phase I) SGX (No Longer in Clinic, per comments)
SGX-393 (Bcr-Abl) SGX
AT-7519 (CDK1, CDK2 Phase I) Astex
VER-52296 or NVP-AUY-922 (hsp90, Phase I/II) Vernalis plus another in Phase I
Gianni Chessari, from Astex, noted this list (from a review coming out soon-ish?), with repeats removed:
AT9283 Astex Aurora Phase 2ABT 869 (VEGF & PDGFR Phase I) Abbott
SGX-523 (Met Phase I) SGX (No Longer in Clinic, per comments)
SGX-393 (Bcr-Abl) SGX
AT-7519 (CDK1, CDK2 Phase I) Astex
VER-52296 or NVP-AUY-922 (hsp90, Phase I/II) Vernalis plus another in Phase I
LY-517717 Lilly/Protherics FXa Phase 2
PLX-204 Plexxikon PPAR agonist Phase 2
ABT-518 Abbott MMP-2 & 9 Phase 1
AT13387 Astex HSP90 Phase 1
IC-776 Lilly/ICOS LFA-1 Phase 1
PLX-4032 Plexxikon B-RafV600E Phase 1
PLX-5568 Plexxikon Kinase Inhibitor Phase 1
SNS-314 Sunesis Aurora Phase 1
LP-261 Locus Tubulin Phase 1
DG051 deCODE LFA4H Phase 1
So, what's missing? I would also be curious as to how these projects progressed.
Update: I have removed duplicates from the two lists. One (SGX-523) has fallen out of the clinic (per comments).
1 comment:
SGX-523 is no longer in the clinic.
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