Practical Fragments

2012 has been a bumper year for fragment conferences and reviews. Starting with the Molecular Medicine Tri-Con in San Francisco, moving so...

How many possible fragments are there? Jean-Louis Reymond and colleagues at the University of Berne have been trying to answer this questio...

This paper , from a consortium  of academics in Holland, Belgium, and Switzerland and a UK pharmaceutical company, reports on inhibitors fo...

Thermodynamics has come up several times on Practical Fragments . The binding of a ligand to a protein can be dissected into enthalpic and e...

Last year we highlighted a paper from AstraZeneca in which they used virtual screening to identify fragments that inhibit the p110β isoform...

Perhaps no other single target so successfully demonstrates the potential of fragment-based approaches as BACE1, a challenging aspartyl prot...

Fierce Biotech has a listing of the top 15 (potential) late stage blockbusters in development.  I think these lists Fierce put out are very...

Fragment-Based Drug Design Down Under was held at Monash University in Melbourne, Australia earlier this month. The first dedicated FBDD ...