Practical Fragments

Despite its ubiquitous use as a model organism, Escherichia coli causes nearly a million deaths each year worldwide. Antibiotics provoke ra...

Last week some 875 people attended the CHI Drug Discovery Chemistry ( DDC ) meeting in San Diego. I can’t do justice to the 40 or so present...

Last week we highlighted work out of Steve Fesik’s lab at Vanderbilt University about PLPro. This week we’ll highlight another paper just p...

The most successful drug against COVID-19, nirmatrelvir, targets the main protease of SARS-CoV-2. As we discussed just last year, this prot...

Since the invention of ligand efficiency ( LE ) more than two decades ago, scholars have been debating its strengths and weaknesses. And alt...

As covalent drug discovery continues to rise, the demand for metrics to help guide lead optimization is increasing. Last year we discussed c...

Despite the effectiveness of vaccines against SARS-CoV-2, COVID-19 continues to plague us. The handful of approved small molecule drugs targ...

Last year we celebrated the ten-year anniversary of the Chemical Probes Portal. One of the key requirements for a chemical probe is selecti...

Among the many biophysical techniques presented at the recent Novalix meeting , hydrogen/deuterium exchange mass spectrometry ( HDX-MS ) was...

Last week the Twelfth Novalix Biophysics in Drug Discovery Conference was held for the first time in La Jolla, California. It’s been severa...

Last month we highlighted a paper from Iwan de Esch and colleagues at Vrije Universiteit Amsterdam about assessing molecular shapeliness....