06 January 2025

Fragment events in 2025

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After a bumper year for conferences in 2024, this year is also shaping up to be eventful.  April 14-17:  CHI’s Twentieth Annual  Fragment-Ba...
30 December 2024

Review of 2024 reviews

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Long winter is here in the global north, with its dim days and gaping nights. As is tradition , Practical Fragments looks back on the year ...
23 December 2024

Covalent fragments vs BFL1: a selective chemical probe

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Last week we highlighted the construction of a covalent fragment library at AstraZeneca. The first fruits of this library have recently bee...
16 December 2024

How to build a covalent fragment library

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Covalent fragment-based lead discovery is becoming ever more popular, driven by success against difficult targets such as KRAS G12C . These...
09 December 2024

They may be cons, but they’re our CONS

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Practical Fragments has written repeatedly about various assay artifacts (vide infra). Different technologies are susceptible to different ...
3 comments:
02 December 2024

Mapping protein conformations with fragments

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Proteins can be remarkably dynamic, and, as we noted recently, different conformational states can reveal different pockets for small molec...
18 November 2024

Covalent fragments vs chikungunya nsP2

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Perhaps because it sounds like “chicken,” when I first heard of chikungunya I thought it was a joke. But there’s nothing funny about a dise...
11 November 2024

Poll results: fragment finding methods and structural information needed for fragment-to-lead efforts

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Our most recent poll asked about fragment finding methods. The poll ran from September 21 through November 8 and received 135 responses fro...