Practical Fragments

Last week’s post highlighted an example of fragment linking, which despite being less common than fragment growing can still be effective ....

Once considered a time-intensive method justified only by the most-promising molecules, crystallography is fast becoming a routine technique...

Recently we highlighted the “Ring Replacement Recommender,” which provides suggestions for how to improve affinity by replacing one ring wi...

So you’ve run a fragment screen, gotten some hits, and validated them. What then? Looking for in-house or commercial analogs is always a go...

A post last month covered high-throughput virtual screening, but most practitioners of FBLD still start with some sort of (bio)physical sc...

What do you do when you find a fragment? After checking for artifacts and getting as much structural information as possible, the next ste...

Last year we highlighted a paper from Yasushi Amano and colleagues at Astellas in which they performed fragment-screening on soluble epoxi...

Last year we highlighted a paper from AstraZeneca in which they used virtual screening to identify fragments that inhibit the p110β isoform...

Richard Silverman, the discoverer of pregabalin , has published a trifecta of papers describing the use of his “fragment hopping”strategy t...