Practical Fragments

Last week we highlighted work suggesting that small molecule binding sites in RNA are most likely to be found in complex structures. A new ...

Most drugs bind to proteins, but RNA provides many interesting targets. Unfortunately, finding drug-like small molecules that bind to RNA is...

The annual Practical Fragments look-back on the preceding year may not be the most highly anticipated year-end tradition, but I hope you f...

Last week’s post focused on fragment screening against RNA, and we continue the theme this week with a paper published in Proc. Nat. Acad....

Fragment-based lead discovery against RNA has been a theme on Practical Fragments for well over a decade. Unfortunately, most of the result...

As the year winds down SARS-CoV-2 continues its relentless drive through Greek letters and the planet. But there is hope: vaccines seem to b...

The first mention of SARS-CoV-2 on Practical Fragments in early March of last year highlighted a crystallographic fragment screen against ...

RNA is hot. Hundreds of millions of dollars have gone to startups focused on finding small molecules that bind RNA, and plenty of large phar...

In templated or in situ reactions, bonds form between two fragments that are brought together in the context of a larger molecule such as a...