Practical Fragments

The metrics ligand efficiency ( LE ) and lipophilic ligand efficiency (LLE or LipE ) are frequently used during fragment-to-lead optimizati...

As 2018 recedes into history, we are using this last post of the year to do what we have done since 2012 – review notable events along wit...

This is the title of a magisterial review by Rob Young of GlaxoSmithKline in Top. Med. Chem. At 68 pages it is not a quick read, but it d...

Of all the topics on Practical Fragments , none have generated as much Sturm und Drang as ligand efficiency ( LE ) and related metrics. B...

Next week is the Drug Discovery Chemistry conference where Dan and I will be co-teaching our award-winning FBDD short course (or at least...

Practical Fragments recently introduced WTF as a light-hearted jab at the continuing proliferation of metrics to evaluate molecules, but...

ret·ro·spec·tive   (r t r -sp k t v) adj. 1. Looking back on, contemplating, or directed to the past. 2. Looking or directed backward...

I recently returned from Philadelphia, where the American Chemical Society held its 244 th national fall meeting. As always this was a ma...

Besides ligand efficiency (LE), a slew of other metrics has been proposed to help evaluate what compounds to take forward in drug discovery....

Molecular Medicine Tri-Con has just ended in San Francisco, and although it is one of those massive conferences with a very wide scope, fro...