Practical Fragments

I recently returned from Philadelphia, where the American Chemical Society held its 244 th national fall meeting. As always this was a ma...

Besides ligand efficiency (LE), a slew of other metrics has been proposed to help evaluate what compounds to take forward in drug discovery....

Our last post discussed the growing plague of molecular obesity, and how numerous metrics have been designed to control it. In a paper publ...

Obesity in humans is a growing problem, and not just aesthetically: the condition may be responsible for millions of premature deaths. In a ...

In last month’s issue of Nature Reviews Drug Discovery , György Keserü of Gedeon Richter and Gergely Makara of Merck published a thought-pro...