Practical Fragments

DOS – diversity-oriented synthesis – intentionally generates a disparate set of compounds from a small number of starting materials in just...

Last week’s post discussed three papers describing new chemistries for building fragment libraries. The theme continues this week with thr...

Among fragment-finding methods , ligand-based NMR ranks near the top in terms of popularity. Of its many variations, fluorine ( 19 F) NMR...

As 2018 recedes into history, we are using this last post of the year to do what we have done since 2012 – review notable events along wit...

Diversity-oriented synthesis, or DOS , enables the rapid and systematic synthesis of multiple related compounds from small sets of molecule...

The meeting Development of Novel Therapies through Fragment Based Drug Discovery was held last week in Houston, Texas, organized by the Gu...

Dan has already hit the highlights of FBLD 2014 .  I won't do the lowlights.  They were few and far between.  I will try to give some f...

The first major fragment event of 2014 drew around 500 people to San Diego last week. This is part of CHI’s three-day Drug Discovery Chemis...

Many drugs have their origins in natural products. But as any synthetic organic chemist will tell you, natural products often have complex a...

A few months ago we highlighted a forum in Nature comparing fragment-based lead discovery with diversity-oriented synthesis, or DOS. This ...

The most recent issue of Nature has a brief but trenchant summary of fragment-based screening (FBS) by Abbott’s Phil Hajduk, of SAR by NMR...