15 January 2014

Poll: how do you store your fragment libraries?

Following up on the recent post on pool size, we thought we’d poll readers on the very practical question of how they store their libraries. I’ve heard some vigorous debates, so it will be interesting to see the results. Please vote on the right side of the page. Also, please note that this question refers to working libraries as opposed to master stocks.
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6 comments:

  1. AnonymousJanuary 16, 2014 4:56 AM

    Since you're asking about storage of the compound, how about adding a poll asking about the concentration of the stock solution and the solvent (DMSO, methanol, aqueous)?

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  2. AnonymousJanuary 16, 2014 8:40 AM

    The atmosphere is important as well, Air or inert, N2, Ar...

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  3. Dr. Teddy ZJanuary 17, 2014 6:45 AM

    I would also be interested to know how frequently people QC their master plates, how they store the main supply (dry or in soln), and so on. I don't think people will be as forthcoming with that information.

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  4. AnonymousJanuary 17, 2014 9:27 PM

    30 mM non deuterated DMSO stock solutions, inert gas, sealed plates. QC once ever two years. Keep solid on hand to create new plates as necessary. This works well for both SPR and NMR screening.

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  5. AnonymousJanuary 18, 2014 5:04 AM

    100 mM in DMSO-d6, inert gas (N2), sealed plates. Have solids on hand to create new plates. Works for thermal shift, NMR, SPR and FP. QC once every two years

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  6. AnonymousJanuary 28, 2014 9:34 AM

    James B. said

    I usually store them as far as possible to my Haut-Lafitte 1959

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