Looking for trouble

Anyone who runs a fragment screen, especially for the first time, is likely to encounter problems. Large companies with sophisticated screening groups generally have a wealth of experience and procedures for dealing with false positives, but smaller organizations and academic labs can all too easily get lured into blind alleys. To help folks avoid these, Ben Davis and I are putting together a mini-review that summarizes the problems that can arise. While there are plenty of examples in the literature, we are also interested in hearing from you about artifacts and other problems that you’ve encountered but either not gotten around to publishing or decided against doing so. Feel free to leave comments here, anonymously if you wish, or email fbldproblems@gmail.com. Thanks – and may all your hits confirm!