A good fragment library is
essential for generating good fragment hits. Earlier this year we asked about
fragment size and library size, and summarized the results here.
Some folks make their own
fragments, but this is expensive, and it’s probably fair to say that most
fragment libraries contain a large fraction of commercially available
compounds. Unfortunately, what you buy is not always what you get: sometimes
the wrong compound is sent, or the compound is not as pure as advertised. As
this post makes clear, different vendors have different track records.
Two years ago we highlighted a
number of fragment library vendors. The current poll first asks whether you’ve
bought fragments in the past several years. (Please answer this question as
otherwise I have no idea how many people actually vote.)
If the answer to the first
question is yes, the second question asks which vendors you would recommend
buying from – presumably because you’ve had good experiences with them in the
past few years. You can vote for as many as you’d like.
Finally, the third question asks
which vendors you would avoid.
Please vote on the right-hand
side of the page, and feel free to leave comments below, particularly if you've used vendors not on the list.
And on the subject of voting, if
you are eligible to vote in the United States, please make sure to do so before
the polls close on November 6.
Democracy atrophies when citizens
don’t exercise their rights.
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