Practical Fragments

Last year we celebrated the ten-year anniversary of the Chemical Probes Portal. One of the key requirements for a chemical probe is selecti...

Among the many biophysical techniques presented at the recent Novalix meeting , hydrogen/deuterium exchange mass spectrometry ( HDX-MS ) was...

Last week the Twelfth Novalix Biophysics in Drug Discovery Conference was held for the first time in La Jolla, California. It’s been severa...

Last month we highlighted a paper from Iwan de Esch and colleagues at Vrije Universiteit Amsterdam about assessing molecular shapeliness....

It’s been a couple years since Practical Fragments last updated our “fragments in the clinic” list . Before doing so it makes sense to high...

Last year we highlighted an example of crystallographic screening of crude reaction mixtures to find inhibitors against the oncology target...

Transcription factors can be difficult drug targets, particularly those whose primary structure is a “leucine zipper” in which two α -helice...

The shape of a molecule influences its properties. While this is true on a per-compound level, things get a little more controversial when d...

Lots of interesting events coming up this year - hope to see you at one! February 17-19 :  The  Twelfth NovAliX Conference  will be held fo...

As covalent drug discovery becomes increasingly common , researchers are becoming more rigorous in how they characterize their molecules. Th...

Turning and turning in the widening gyre The falcon cannot hear the falconer…   In our small, annual counterweight to Yeats’ “ mere a...