Practical Fragments

A special case of fragment linking is dimerization, in which two copies of the same fragment bind to adjacent sites in a protein and are su...

Protein-protein interactions (PPIs) can be difficult targets for multiple reasons. First, the contacts often cover large, flattish areas wi...

Our latest poll (please vote on the right-hand side of the page!) is about fragment libraries. Once you have your library, you can screen ...

Ten years ago today Teddy launched Practical Fragments with a simple question about screening methodologies. More than 660 posts later we...

Hard to believe we're already halfway through the year, but there are still some exciting events ahead, and 2019 is already starting to...

The first fragment-based drug  to reach the market, vemurafenib , targets a mutant form of the kinase BRAF. Initial responses can be miracu...

Last week NovAliX  held its biophysics meeting  outside of Strasbourg for the first time. Naturally they chose Boston, one of the most Euro...

Most of the papers Practical Fragments cover are limited in scope: a new chemical probe , say, or an NMR method. Even in our annual re...

A few weeks ago we highlighted the story of eFT508, a clinical MNK1/2 inhibitor derived from a previously published fragment. One of the c...

Anyone who has spent much time in drug discovery will have been asked what they've done to cure the common cold. In a paper just publis...

A common question in library design concerns novelty: should you populate your library with custom-made, hitherto unseen molecules, or ju...

Of the 30+ fragment-derived drugs that have entered the clinic , only one is an antibiotic. In part this reflects a shift away from this t...

Practical Fragments has covered virtual screening for nearly ten years, and the tools continue to improve. More recently , researchers are...

Mycobacterium tuberculosis (Mtb) , the cause of its eponymous disease, is making an unwelcome comeback. Current treatments are lengthy, an...

Multiple clinical candidates derived from fragments were described at the recent CHI FBDD Meeting. The story behind one of these has just...

As mentioned last week, CHI’s FBDD Meeting was chock-full of success stories. Some of these have recently been published, including work ...

CHI’s Drug Discovery Chemistry (DDC) meeting was held last week in San Diego. The event continues to grow, and this year hosted some 800 at...