Practical Fragments

Most drugs interact non-covalently with their target. The conventional wisdom was that covalent drugs – especially irreversible ones – wo...

One of the more exciting phenomena in fragment-based approaches is synergy (or superadditivity), in which the binding energy of linked fra...

Epigenetics is big .  Wicked big.  How big?  This big .  Papers come from everywhere.  In this paper , an academic group from Minnesota, go...

One of the key selling points of fragment-based lead discovery is that small fragments can search chemical space much more efficiently than...

Dan and I don't see every fragment paper and so it's nice when people point out papers to us.  Its typically their recently publish...

About half of all approved drugs are small molecules that inhibit enzymes. This makes sense intuitively: an enzyme is like a complicated li...

We are all about new methods here.  One method I have never been a big fan of is Weak Affinity Chromatography, which has been reviewed here...

One of the more popular applications of fragment-based lead discovery has been targeting protein-protein interactions . Among these, the BC...

So, not everybody agrees with me on what a fragment is .  As has been pointed out years ago, FBDD can be a FADD .  In this paper , from ea...