Practical Fragments

A recent discussion centered on whether fragment libraries should be designed to include more “3-dimensional” molecules and reduce the numb...

Fragment-based lead discovery owes much of its popularity to NMR: the SAR by NMR papers published by Abbott in the mid 1990s demonstrated b...

Two deals involving companies in the fragment space were announced today. I don’t have inside information on either of these, but superficia...

For those of you who haven’t heard, Warren Delano, author of PyMOL , died earlier this week. His sister Jen has established a blog for peop...

What can you do with fragments? The idea of linking a couple together, while successfully demonstrated in the first SAR by NMR paper , gene...

In what we hope is a new series bringing the latest in Fragment Science up for discussion, we present today to you a discussion of Infarmati...

Heidelberg-based Graffinity today announced that they would be collaborating with the Genentech division of Roche. Graffinity will apply i...

We’re in the last quarter of 2009, and I know of just one more event this year involving fragments: October 13 : The Life Science Regional T...

Last year we highlighted a paper that touched on some of the ways crystal structures can mislead, and a theme of FBLD 2009 was how dubious...

Fragment-based Lead Discovery Conference 2009 just concluded in York, UK; it was the second in what will hopefully be a continuing series....

There is an upcoming conference with an extraordinary FBDD lineup. :-) Don Huddler from GSK will be talking about SPR in fragment screening...

Lots of companies are using FBDD, but aside from big pharma it’s not always easy to find them. As a public service we have started a running...

Pennsylvania-based BioLeap , which uses computational FBDD, has just signed a deal with GlaxoSmithKline to work on “difficult” targets. The...

Our friends over at FBDD-Literature have already highlighted this, but it bears repeating that the entire August issue of J. Comp. Aid. Mo...

Crystallography-based methods of fragment screening often rely on growing many crystals of a protein and soaking these in fragment-containin...

The phenomenon of aggregation is the drug hunter’s quicksand. A prerequisite for using biochemical assays to study fragments – or any low-af...

Dynamic combinatorial chemistry (DCC) has grown alongside of and often intersected with FBDD. In a recent issue of Angewandte Chemie , Jörg ...

A couple months ago we highlighted research suggesting that natural products are a fruitful field for finding fragments. One company, deCOD...

Proving again that Hsp90 is tailor-made for fragment-based approaches , the latest issue of J. Med. Chem. has a thorough article describin...

Hard to believe, but 2009 is more than halfway over. As far as I know there is only one more event this year focused primarily on fragments,...