Practical Fragments

This blog is meant to allow Fragment-based Drug Design Practitioners to get together and discuss NON-CONFIDENTIAL issues regarding fragments.

Showing posts with label stabilization. Show all posts

Showing posts with label stabilization. Show all posts

01 June 2026

From covalent to noncovalent 14-3-3 modulator, unintentionally

The seven members of the 14-3-3 family act as “hub proteins” that bind to other proteins, bringing them together or affecting their subcellu...

14 August 2023

Stabilizing protein-protein interactions: part 3 (fragment linking)

Stabilizing protein-protein interactions is becoming increasingly popular, and not just for PROTACs . Nearly three years ago we highlighted ...

12 October 2020

Stabilizing protein-protein interactions: part 2

Stabilizing – rather than disrupting – protein-protein interactions is increasingly popular, particularly in the context of PROTACs and mol...

04 March 2019

Stabilizing and destabilizing SOS1-RAS interactions

Last week we highlighted an example of fragments stabilizing a protein-protein interaction. This week continues the theme, with a paper p...

25 February 2019

Stabilizing protein-protein interactions

Despite the fact that the second FDA-approved fragment-derived drug targets a protein-protein interaction (PPI), these types of targets ha...

15 July 2015

Covalent Inhibitor of KRas

So, Ras is big. We keep on talking about it. And sometimes we talk about the same work repeatedly. This recent paper from AZ is a public...

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