Practical Fragments

This blog is meant to allow Fragment-based Drug Design Practitioners to get together and discuss NON-CONFIDENTIAL issues regarding fragments.

Showing posts with label phosphodiesterase. Show all posts

Showing posts with label phosphodiesterase. Show all posts

12 March 2018

Fragments vs PDE10A: Astellas’ turn

The 11 members of the phosphodiesterase (PDE) family cleave cyclic nucleotides such as cAMP and cGMP to regulate cell signaling. These enzy...

21 May 2014

Enthalpy arrays revisited: PDE10A

Two years ago we highlighted enthalpy arrays: very tiny temperature sensors that measure the heat generated during the course of an enzymat...

16 January 2012

Enthalpy Arrays

As regular readers know, there are lots of ways to find fragments , each with its own strengths and weaknesses. Isothermal titration calorim...

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