Practical Fragments

Practical Fragments has written frequently about hot spots , regions on proteins that are predisposed to bind ligands such as drugs. Determ...

Practical Fragments has written several times about “ hot spots ”: regions on proteins where small molecules and fragments readily bind. Kn...

Computational approaches to FBLD continue to gain in power. For the most part, they require significant knowledge and installation of expens...

Scientists generally want structural information when a project begins, and ideally that structural information comes from crystallography....

Several recent Practical Fragments posts have touched on crystallographic screening : from ultra-high concentration screening of “ MiniFra...

This is the last week for our poll on how much structural information you need to begin optimizing a fragment – please vote on the right-h...

Earlier this year we highlighted crystallographic work out of Astex showing that secondary ligand binding sites on proteins are common; in...

In the eight years since Practical Fragments first started, Moore’s law has held strong and computational power has increased accordingly...

In the Northern Hemisphere the winter solstice has passed but the days are still short, and 2015 is hurtling into history. As we did in 201...

Say you have a protein target, and you want to know whether you will be able to find small molecules that bind to it. A fragment screen can...

The protein p97 is important in regulating protein homeostasis, and thus a potential anti-cancer target. But this is no low-hanging fruit: ...

The proverb "well begun is half done" suggests that getting started comprises much of the work. Such is the case for fragments th...

Practical Fragments has previously written about the concept of hot spots – regions on a protein where fragments are particularly prone...