Practical Fragments

This blog is meant to allow Fragment-based Drug Design Practitioners to get together and discuss NON-CONFIDENTIAL issues regarding fragments.

Showing posts with label fragment libraries. Show all posts
Showing posts with label fragment libraries. Show all posts
14 June 2026

Vast fields of biologically active chemical space

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Exactly 17 years ago, I  highlighted a paper from Brian Shoichet’s lab in which he hypothesized that only tiny regions of chemical space ar...
14 April 2025

A library of covalent fragments vs a library of kinases

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Protein kinases have proven to be a fruitful class of targets, as evidenced by more than 80 FDA-approved drugs, five of which came from fra...
07 April 2025

Do covalent fragments need to be larger?

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A few months ago we highlighted work out of AstraZeneca detailing how to build a covalent fragment library. One of the design features was ...
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16 December 2024

How to build a covalent fragment library

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Covalent fragment-based lead discovery is becoming ever more popular, driven by success against difficult targets such as KRAS G12C . These...
29 May 2023

Poll results: fragment libraries in 2023

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Our latest poll on fragment libraries suggests the field is settling into some standard practices. The poll ran from April 9 through May 26...
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