Practical Fragments

The year ends, and with it the awkward teenage phase of the twenty-first century. As we have done since 2012 , we're using this last p...

Last year we discussed the application of dynamic combinatorial chemistry ( DCC ) to fragment linking. The idea is that a protein will shif...

Last December the first-ever  Pacifichem  symposium on FBLD was held in Honolulu. Two of the organizers, Martin Scanlon and Ray Norton, inv...

Dynamic combinatorial chemistry ( DCC ) sounds incredibly cool. The idea is that libraries spontaneously form and reform. Add a protein an...

Of the many ways to link fragments, one of the most intriguing is when the protein itself catalyzes or templates the assembly of two fragmen...

Dynamic combinatorial chemistry (DCC) has grown alongside of and often intersected with FBDD. In a recent issue of Angewandte Chemie , Jörg ...