Practical Fragments

Accurately and reliably predicting fragment binding modes would be preferrable to doing messy, expensive, and sometimes tedious experimental...

As experienced practitioners of fragment-based lead discovery will know, the best way to avoid being misled by artifacts is to combine multi...

Computational approaches to FBLD continue to gain in power. For the most part, they require significant knowledge and installation of expens...

Growing fragments is probably the most common approach to improving affinity, and it is immeasurably faster to do this virtually than exper...

NMR was the first practical fragment-finding method, and continues to be popular . Just over the past year we’ve discussed several new tech...

Docking can sometimes seem like the Rodney Dangerfield of FBDD: it don’t get no respect. In last year’s poll of fragment finding methods,...