Practical Fragments

Roughly speaking there are three ways to advance fragments to leads: growing, linking, or merging. Growing is the most common , but as the n...

Successful fragment-based lead discovery typically starts with a good library. But what is “good”? Given that most fragment libraries are sm...

In our latest poll, we asked what kind of libraries people like, giving three options: I like a maximal diverse library (SAR comes ...

A few months ago we highlighted a forum in Nature comparing fragment-based lead discovery with diversity-oriented synthesis, or DOS. This ...