Practical Fragments

It’s been a while since our last “getting misled by crystal structures” post . That one described unrecognized conformational heterogeneity ...

The ten human fatty-acid binding proteins (FABPs) shuttle lipids around cells. As we noted several years ago, FABP4 and FABP5 are potential...

Back in 2017 we observed with characteristic subtlety that “heavy metals suck.” That post described a hit-finding campaign which foundered ...

The rise of high-throughput crystallography is among the most exciting recent developments for fragment finding. Historically deemed too sl...

Using biochemical assays to find fragments sidesteps the need for expensive biophysical instruments, but is fraught with difficulties . In a...