Practical Fragments

Among the various fragment-finding methods, capillary electrophoresis (CE) seems to be among the least-used, at least according to our poll...

Among the many ways to find fragments, one of the relatively inexpensive newcomers is weak affinity chromatography, or WAC (see also here...

Lipophilicity is a topic that comes up periodically . Lipophilic molecules are increasingly viewed as problematic from a drug development s...

Last year we highlighted a fragment-finding technique called weak affinity chromatography , or WAC. Those of you who were at FBLD 2012 ...

Practical Fragments has a soft spot for new biophysical methods to identify fragments, many of which are given unfortunately non-descriptiv...

One of the fun aspects of fragment-based lead discovery is the number of ingenious biophysical methods for finding low-affinity fragments...

There are many ways to find fragments: NMR and X-ray crystallography are old favorites, but SPR is quickly catching on. There are also more...