Practical Fragments

This blog is meant to allow Fragment-based Drug Design Practitioners to get together and discuss NON-CONFIDENTIAL issues regarding fragments.

Showing posts with label carbonic anhydrase. Show all posts
Showing posts with label carbonic anhydrase. Show all posts
12 October 2026

Focal molography for assessing protein-ligand interactions

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The list of technologies used to find and validate fragments is long, with more than a dozen in our 2024 poll . But it’s always fun to learn...
15 February 2010

Surface Plasmon Resonance (SPR)

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Fragment-based drug discovery took off with NMR in the 1990s and went mainstream with X-ray crystallography in the 2000s. Now surface plasmo...
3 comments:
03 December 2009

Enthalpy versus entropy

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The earliest stages of lead discovery usually focus on obtaining a molecule with decent affinity for a given target. Affinity, or binding en...
1 comment:
15 March 2009

Fragments on Glass

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I’m always a fan of new fragment technologies, and Hioryuki Osada and colleagues at RIKEN have just published a very intriguing one which th...
2 comments:
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