Practical Fragments

FBLD 2014 , the fifth in an illustrious series of conferences, took place in Basel, Switzerland last week. Organizers Wolfgang Jahnke ( No...

One of the key advantages of fragment-based drug discovery is that, since there are fewer fragments than lead-sized or drug-sized molecules,...

Earlier this year we highlighted a paper from Vernalis that described the use of NMR methods to discover inhibitors of the anti-cancer targ...

Pin1, a potential anti-cancer target, catalyzes isomerization around phosphoserine-proline and phosphothreonine-proline bonds. Its binding s...

A recent discussion centered on whether fragment libraries should be designed to include more “3-dimensional” molecules and reduce the numb...