Practical Fragments

Transcription factors can be difficult drug targets, particularly those whose primary structure is a “leucine zipper” in which two α -helice...

In order to thrive, cancer cells need to evade the immune system. Preventing them from doing so is the goal of cancer immunotherapy . Althou...

The year ends, and with it the awkward teenage phase of the twenty-first century. As we have done since 2012 , we're using this last p...

Earlier this year we highlighted the discovery of AZD5991, a phase 1 compound from AstraZeneca that inhibits the anti-apoptotic cancer tar...

I know you all come here looking for pithy breakdowns of recent publications in the fragment world.  Today Dan and I are both in Boston at ...