Practical Fragments

Chemical probes can be incredibly powerful reagents for understanding biology. A potent, selective, and cell-active modulator of a specific...

As regular readers may have discerned, I’m favorably disposed to most of the papers I highlight. They may have flaws or inconsistencies, bu...

Pan-assay interference compounds – PAINS – are a topic that has come up repeatedly at Practical Fragments (see here , here , and here for...

I grew up on a wonderful little island called Jamestown (although technically it is Conanicut island and the town is Jamestown).  It was a ...

So, as regular readers know, we have declared war on PAINS on the blog.  As part of that effort, I (we?, not sure if Dan wants to be associ...

Practical Fragments has previously noted that many pan-assay interference compounds ( PAINS ) can be found in nature . Indeed, they’ve als...

Just a quick heads-up that Celia Arnaud has a nice story on pan-assay interference compounds ( PAINS ) in the latest issue of Chemical and...

Dan and I teach a short course on FBDD; next chance to catch a version in October .  My favorite part of Dan's section is when he goes...