Practical Fragments

One of the advantages of running lots of fragment screens is that it generates lots of data that you can mine for general trends and insigh...

FBLD 2014 , the fifth in an illustrious series of conferences, took place in Basel, Switzerland last week. Organizers Wolfgang Jahnke ( No...

Renin, an aspartic protease involved in regulating blood pressure, is one of those drug targets that has been around forever; it took decade...

The protein farnesyl pyrophosphate synthase (FPPS) has long been a target of drugs for osteoporosis, and some data have suggested it could b...

A common concern with using biophysical techniques to identify fragments is that the functional implications of identified binders are not a...

The spring national meeting of the American Chemical Society has just concluded in (uncharacteristically sunny) San Francisco. The main frag...