Practical Fragments

The 2017 International Symposium on Fragment Based Lead Discovery (pdf here ) was held in Shanghai, China last week. I was fortunate to be ...

CHI’s Drug Discovery Chemistry meeting took place over four days last week in San Diego. This was easily the largest one yet, with eight t...

Bromodomains have nothing to do with bromine. Rather, they are small (~110 amino acid) domains that recognize acetylated lysine residues, ...

One of the less commonly used fragment-finding methods is microscale thermophoresis ( MST ). This measures the movement of proteins in a t...

Our current poll (right-hand side of page) asks about NMR. But of course, there are lots of other ways to find fragments, and the question...

Practical Fragments has a soft spot for new biophysical methods to identify fragments, many of which are given unfortunately non-descriptiv...