Practical Fragments

Fragment growing has been the dominant strategy of most of the recent posts involving lead optimization, consistent with our poll results ....

The results of our latest poll are in – thanks to all who participated! Of the 119 people who responded to the first question, 87% said th...

Among fragment-finding techniques, nuclear magnetic resonance (NMR)  ranks near the top . Protein-detected methods, like HSQC/HMQC-based SA...

I have been on a bit of a jag lately pummeling academic "Drug discovery".  Dan recently hopped on, in his much more circumspect...

We’ve pointed out potential pitfalls with crystallography ( here , here , and here ) as well as with biochemical screening , but NMR has esc...