Practical Fragments

Fragment linking is one of the most seductive forms of fragment-based lead discovery: take two low-affinity binders, link them together, and...

There has been no shortage of fragment-based approaches directed toward the anti-cancer target Hsp90, most of which have relied on growing f...

The spring national meeting of the American Chemical Society has just concluded in (uncharacteristically sunny) San Francisco. The main frag...

The first event on our 2010 calendar , the Molecular Medicine Tri-Conference 2010 , was held in San Francisco earlier this week. There were ...

Two reviews in the July issue of Drug Discovery Today provide an update on the state of FBDD. The first , from researchers at the VU Univer...

Back in October of last year we highlighted a paper in Science that disclosed a new antibiotic targeting the bacterial protein FtsZ. The ...