Practical Fragments

For those of you who have been reading this blog for a while, you are familiar with the "Fragments in the Clinic" posts, Jan2015 ...

Last week marked the tenth anniversary of CHI’s three-day Drug Discovery Chemistry conference in San Diego. The conference consists of six...

When I was in grad school, I was faced with the choice of two NMR labs to join (after starting as a organic chemist and flirting with enzym...

One of the most well-known examples of a fragment-based program that has yielded a clinical compound is Abbott’s Bcl-2 effort: ABT-263 is cu...

A frequent topic in fragment roundtable discussions concerns specificity: do fragments hit lots of targets, or just a few? Isabelle Krimm an...

Although most people try to advance fragments to more potent molecules, some have taken the reverse approach: starting with potent binders a...

A new paper describes how combining fragment classes that selectively react with each other can yield an inhibitor to a protein-protein int...