Practical Fragments

Getting from a fragment to something more useful can be time consuming, and frustrating. Often it requires making lots of inactive analogs. ...

Last week CHI held Discovery on Target – virtually of course. There were 20 tracks over three days and more than 650 attendees, down from 1...

The last fragment-relevant conference of 2020 is happening this week – virtually of course. I attended my first virtual conference last mon...

As evident at the CHI Drug Discovery Chemistry meeting a couple weeks ago, covalent fragment-based lead discovery is becoming increasingly ...

What a strange year for conferences! Everything fragment-related in the first half of the year was canceled or rescheduled. And when it tur...

Of the dozen-plus methods to find and characterize fragments, only two have historically been able to provide detailed binding information:...

The RAS family of proteins is implicated in roughly one third of cancers, and as such has been a long-standing target for drug discovery. Ea...

Advancing fragments in the absence of structural information has a reputation for being so challenging that some people do not even attempt ...

In templated or in situ reactions, bonds form between two fragments that are brought together in the context of a larger molecule such as a...

The ideal shape of compounds used for biological screens is a subject of vigorous debate, with some arguing that shapely molecules may be ...