Practical Fragments

A few weeks ago we gave a passing nod to work by Jean-Louis Reymond, who with colleagues enumerated all possible compounds with up to 11 C...

One of the promises of fragment-based methods is that they can tackle “hard” targets such as protein-protein interactions and nucleic acids....

A couple months ago I considered writing an April Fools’ post on screening fragments in vivo. A recent paper in J. Med. Chem. reports som...

In a previous post about heterocycles that appear chemically feasible but have not been reported, we wondered whether these molecules would...

I have a question for the followes/readers here. Is there a hidden talent pool of recent Ph.Ds who have training in FBDD and can immediatel...

We recently provided a list of suppliers of commercial fragment libraries . A problem with buying compounds from these sources, of course, i...

With 16 days left to vote (Use you franchise!!!) 17 of 20 respondents have said that FBDD is integrated in the hit finding stage at their co...

Teddy recently observed that it’s not the size of your library that matters, but how you use it. But how do you get a fragment library in t...

Boys will be boys, won't they. There is some gene buried on the Y chromosome that makes them think if something works as is, the bigger...

One of the most rewarding fragment-based outcomes is to link two fragments together and get a pop in activity, as predicted by William Jen...

A few weeks ago, we highlighted a paper from Brian Shoichet’s group at UCSF demonstrating that computational screening could successfully ...

It seems the fragment calendar was front-loaded this year, but there are still a few upcoming events. June 8-9 : GTCbio is holding its “ Fou...

In last month’s issue of Nature Reviews Drug Discovery , György Keserü of Gedeon Richter and Gergely Makara of Merck published a thought-pro...

There is a review just publish ASAP in JACS of the Zartler and Shapiro edited book on FBDD . Overall, it is a nice review (Thanks to Andrew ...

In what can only be seens as a cosmic convergence, a second paper has appeared on NMR-X-ray hybridization . This one is a collaboration fro...

There is often a competition, explicit or implied, between NMR spectrometrists and X-ray crystallographers. A new technique merges the best...

Of the fragment-derived drugs that have entered the clinic , roughly half target protein kinases. Phil Hajduk (of SAR-by-NMR fame) and Irin...

I’ve always been something of an empiricist, and have therefore been wary of computational fragment screening. It’s not that I think it’s im...

I’m always a fan of new fragment technologies, and Hioryuki Osada and colleagues at RIKEN have just published a very intriguing one which th...

Just a few quick thoughts on RSC BMCS Fragments 2009 , which I had the pleasure of attending at AstraZeneca’s beautiful new conference cente...