tag:blogger.com,1999:blog-1136153439451224584.post5600044705858721770..comments2024-03-27T06:45:59.174-07:00Comments on Practical Fragments: Polypharmacology for KinasesDr. Teddy Zhttp://www.blogger.com/profile/07288045760981372367noreply@blogger.comBlogger6125tag:blogger.com,1999:blog-1136153439451224584.post-63936442396645657142016-07-28T13:02:28.117-07:002016-07-28T13:02:28.117-07:00Dr. Hulme is this you?Dr. Hulme is this you?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-1136153439451224584.post-15242244066112064812016-05-24T02:39:07.850-07:002016-05-24T02:39:07.850-07:00Former IP lawyer here (hey milkshake-long time no ...Former IP lawyer here (hey milkshake-long time no see) figured I remembered these examples from over a decade ago, See WO 2006/108640, the investigator Dr Hong yu Li should respond to these comments of the origin because this is blatant fraud almost as there is no mention of composition of matter. These compounds are mentioned in the patent nearly explicitly.. Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-1136153439451224584.post-89517508824475861662016-02-03T13:10:49.487-08:002016-02-03T13:10:49.487-08:00Academic group led by an industry veteran. Academic group led by an industry veteran. Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-1136153439451224584.post-51854617959583457812015-12-29T09:38:36.547-08:002015-12-29T09:38:36.547-08:0015 years ago by a group at Novartis. See WO 2006/...15 years ago by a group at Novartis. See WO 2006/108640. With a publication like this coming from an academic group, it would be nice to see some novel methods/ideas/chemistry as opposed to deconstructing a known multikinase inhibitor and slapping a few buzz words (polypharmacology and fragment-based discovery) in the title.Rocketnoreply@blogger.comtag:blogger.com,1999:blog-1136153439451224584.post-46558882545740898522015-09-04T18:09:35.314-07:002015-09-04T18:09:35.314-07:00I assume the actual work was performed about 15 ye...I assume the actual work was performed about 15 years ago.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-1136153439451224584.post-10784374782696176872015-09-02T21:26:37.763-07:002015-09-02T21:26:37.763-07:00I think what they have done was completely traditi...I think what they have done was completely traditional medicinal chemistry with modeling. Nothing wrong with it. Just a little oversold and misrepresented.Anonymousnoreply@blogger.com