tag:blogger.com,1999:blog-1136153439451224584.post3884021704772395323..comments2024-03-27T06:45:59.174-07:00Comments on Practical Fragments: DCC and FBDDDr. Teddy Zhttp://www.blogger.com/profile/07288045760981372367noreply@blogger.comBlogger1125tag:blogger.com,1999:blog-1136153439451224584.post-85939742705088179282009-09-02T05:31:45.934-07:002009-09-02T05:31:45.934-07:00Hi,
I don't think that this example is a real...Hi,<br /><br />I don't think that this example is a real example of an improved fragment linking approach because the aldehyde part is here a peptide and not a fragment. There are two difficulties in the DCC - fragment linking approach :1) find the first fragment that can be modified with an aldehyde group (or an unique amine) and 2) find the second fragment with the DCC technique. <br /><br />So for me, I think that here it is a VERY GOOD example of how to ADAPT a fluorescence assay to find fragments, but not an example of fragment linking as you say in your conclusion.<br /><br />LionelLionelnoreply@blogger.com