tag:blogger.com,1999:blog-1136153439451224584.post3115699677679826986..comments2024-03-18T02:52:17.621-07:00Comments on Practical Fragments: Small but PAINfulDr. Teddy Zhttp://www.blogger.com/profile/07288045760981372367noreply@blogger.comBlogger4125tag:blogger.com,1999:blog-1136153439451224584.post-29728804636617535152010-11-04T15:35:48.984-07:002010-11-04T15:35:48.984-07:00Also, I would hope that anyone who found a screeni...Also, I would hope that anyone who found a screening hit would at least run a SciFinder search on the substructure. Running such a search on Compound 4 reveals that it's name is "toxoflavin". Certainly one needn't think any more about such a structure . . .Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-1136153439451224584.post-84119900484397132702010-10-30T03:44:37.412-07:002010-10-30T03:44:37.412-07:00Compound 3 looks 'quinone-like' and I'...Compound 3 looks 'quinone-like' and I'd expect it to be both electrophilic and a respectable electron acceptor. These characteristics are not unrelated.Peter Kennyhttps://www.blogger.com/profile/12180360326821860667noreply@blogger.comtag:blogger.com,1999:blog-1136153439451224584.post-7990309666852684462010-10-28T03:13:40.152-07:002010-10-28T03:13:40.152-07:00Thanks for the heads-up on this article. It's ...Thanks for the heads-up on this article. It's a important to highlight these compounds early in the process, and this filter is of big help.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-1136153439451224584.post-31785926273246335292010-10-27T12:57:02.466-07:002010-10-27T12:57:02.466-07:00Alas, we are destined to see ever more of the type...Alas, we are destined to see ever more of the type of disclosures that Baell laments in the future. As companies lay off experienced drug discoverers, as academia starts exploring fields with which they are unfamiliar, as more drug discovery is done in 3rd world countries, these types of systematic mistakes are going to show up more frequently. That's why papers like this are so important, and need to be publicized and re-printed ad nauseam. A couple of my colleagues were discussing this paper and commenting that they didn't learn much from it. "Dude, we're not the audience."<br /><br />Institutional knowledge is drying up -- efforts that try to document "common knowledge" need to be more regularly applauded.Anonymousnoreply@blogger.com